SARSUAG EXPERIENCE AND EXPERTISE

• Antibody development : Monoclonal and polyclonal antibodies, Cascade immunization.
• Antibody purification : Anti-drug antibodies, neutralizing antibodies, analogue specific antibodies, protein A, G.
• Antibody conjugation Biotin, HRP and FITC.
• Antibody HCP characterization : Antibody isotype, anti-HCP antibody and HCP antigen characterization using 1D,2D western blot.
• Cell based and non-cell based Nab assay development : Functional enzyme inhibitor based non-cell based assay and radiolabeled and unlabeled functional metabolic assay.
• Immunoassay development/qualification : Specific, sensitive serum based-PK, Immunogenicity (3 tier approach- ADA screening, confirmatory, and neutralizing antibodies assay titration analysis), Commercial kit optimization, antibody pairing.
• Immunoassay non-serum based CMC assay development : HCP assay (E.coli, Pichia and CHO) and Protein A .